Following the sudden death of U.S. Senator Lindsey Graham of South Carolina, widespread news reports indicate he suffered from an aortic dissection. The American Heart Association (AHA) has provided key facts about this life-threatening condition to raise awareness and emphasize the need for prompt medical attention.
An aortic dissection is a tear in the inner layer of the aorta, the body's largest artery. Blood surges through the tear, causing the layers of the aortic wall to separate. This is a medical emergency that can be rapidly fatal if not diagnosed and treated promptly. The aorta carries oxygen-rich blood from the heart to the rest of the body, and when the aortic wall is weakened, it can either bulge (aneurysm) or tear (dissection).
Symptoms of aortic dissection include sudden, severe chest pain; back pain; neck or jaw pain; and feeling faint, weak, or short of breath. These symptoms can mimic other cardiovascular emergencies, making rapid diagnosis essential. A ruptured aneurysm or severe aortic dissection can be immediately fatal, but prompt diagnosis and treatment can be lifesaving.
According to AHA volunteer president Manesh Patel, M.D., FAHA, “Aortic dissection, a life-threatening disorder, is more common in men than women, with an estimated incidence of 5 to 30 people per million. Most people experience a dissection between the ages of 50-70. Risk factors for this life-threatening condition include atherosclerosis (hardening of the arteries) and high blood pressure. There are some genetic disorders of connective tissue that lead to aneurysms and aortic disease in younger adults.” Patel emphasized that people with risk factors including high blood pressure, tobacco use, or family history of aortic aneurysms or dissections should discuss aortic aneurysm risk and screening with their physicians.
The 2022 American Heart Association/American College of Cardiology Guideline for the Diagnosis and Management of Aortic Disease emphasizes rapid recognition and treatment of acute aortic syndromes, family screening including genetic testing and imaging for first-degree relatives of patients with certain aortic aneurysms or aortic dissection, and consistent imaging and surveillance practices. These guidelines are crucial for improving outcomes in a condition where time is of the essence.
For business and technology leaders, understanding aortic dissection is important not only for personal health but also for corporate wellness programs. The sudden loss of a leader like Senator Graham highlights how quickly this condition can strike, potentially impacting organizations dependent on key individuals. Companies may consider incorporating cardiovascular screening into executive health check-ups, especially for those over 50 with risk factors. The AHA's resources, including the full guideline, provide actionable information for both individuals and organizations to mitigate risks.
The American Heart Association receives more than 85% of its revenue from sources other than corporations, including contributions from individuals, foundations, and estates. It has strict policies to prevent any donations from influencing its science content and policy positions. Overall financial information is available here.
For more information on aortic disease, the AHA provides additional resources, including the 2022 news release on the guideline and a consumer news story on how the new guidelines revise diagnosis and treatment. The full guideline is available at 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease.

