Creative Biolabs, a biotechnology service provider specializing in immuno-oncology research, has announced an exclusive webinar titled "Modeling T Cell Dysfunction in Tumor Microenvironments," scheduled for September 1, 2026, at 10:00 AM EDT. The live virtual event will feature a keynote presentation by Dr. Greg M. Delgoffe, Professor of Immunology at the University of Pittsburgh and Director of the Tumor Microenvironment Center at the UPMC Hillman Cancer Center.
The tumor microenvironment (TME) is a complex ecosystem where cancer cells, immune cells, and metabolites interact. As tumors progress, they create a metabolically challenging environment characterized by nutrient depletion and accumulation of immunosuppressive byproducts. These conditions impair immune cell function, leading to T cell dysfunction, immune evasion, and reduced response to standard cancer immunotherapies. Understanding these interactions is critical for developing effective treatments.
Traditional models often fail to capture the nuanced interplay between tumor metabolism and immune regulation. Dr. Delgoffe's presentation will explore innovative approaches using advanced preclinical testing services and robust in vivo and in vitro models to better replicate metabolic stress conditions. These systems provide researchers with valuable tools to investigate immune suppression and therapeutic responses under physiologically relevant conditions.
"Understanding how metabolic conditions within tumors influence immune-cell behavior is increasingly important in immuno-oncology," said a senior scientific director at Creative Biolabs. "Dr. Delgoffe's work provides an important perspective on how researchers can model these conditions and investigate target discovery and validation."
Webinar highlights will include: how tumor metabolic environments contribute to immune suppression and T cell exhaustion; strategies for modeling TME conditions in preclinical research systems; the mechanisms underlying T cell exhaustion and how nutrient depletion influences T cell function; and how immunometabolism insights can guide therapeutic strategies to enhance cancer immunotherapy.
This webinar is particularly relevant for cancer immunology researchers, pharmaceutical and biotechnology professionals, and R&D teams focused on oncology drug discovery. The event underscores the growing importance of immunometabolism in cancer research and the need for sophisticated models to translate findings into clinical applications.
For registration and more details, visit the webinar page at Creative Biolabs Webinar.
